Thyroid Disorders and Iodine Deficiency in a Pregnant Population

Abstract

INTRODUCTION: The dysfunction, thyroid autoimmunity (AIT) and iodine deficiency in pregnancy, leading to adverse effects. In the absence of prevalence data and ranges of Thyrotropin (TSH) in each quarter in Argentina, international guidelines of American Thyroid Association (ATA) are used. OBJECTIVES: To determine a) prevalence of AIT, thyroid dysfunction and iodine deficiency by screening in healthy pregnant b) TSH reference values per quarter and prevalence of dysfunction with own values. METHODS: We studied 217 healthy pregnant. TSH, T4 and T3 total and free, antibodies to thyroid peroxidase (ATPO) and urinary iodine was determined. Excluding positive ATPO and clinical dysfunction, 5th and 95th TSH percentiles was recalculated and established own TSH ranges. Percentage of pathological TSH values was established according to published ranges and with own values. RESULTS: ATPO were positive in 8% of patients. Goiter was found in 38%. The iodine level was> 150 μgr / dl in 58%. TSH values (median and range) were: 0.95 mIU / ml (0.20- 3.30), 1.50 mIU / ml (0.02-7.00) and 1.60 mIU / ml (0.21-4.90) for the first quarter, the second and third respectively. The TSH was elevated as guides ATA in 11% and in 6.5% as own values. Only one patient had clinical hypothyroidism. CONCLUSIONS: The prevalence of ATPO was similar to that reported, and almost 40% had mild goiter, considered adaptive. Clinical hypothyroidism was recorded at 0.5% and subclinical in 11% as guides ATA, which fell to 6.5% as own values. The median urinary iodine indicated iodine sufficiency in the populatio.